Clinical Sports Medicine International
 
 
 The Journal Of All Movement Related Medical Topics In Health & Disease
 
     
 impressum 
CSMI 2013

Effects of a 6 months recreational training on inflammatory and lipid markers in diabetic patients with oral medication

Antina Schulze, DDS.2, Martin Busse, MD1

General Outpatient Ambulance1 and Sports Dentistry2 of the Institute of Sports Medicine, University of Leipzig
(1Director: Prof. M.W. Busse, MD 2Head: A. Schulze, DDS)

Summary

Schulze A, Busse M. Effects of a 6 months recreational training on inflammatory and lipid markers in diabetic patients with oral medication. Clinical Sports Medicine International (CSMI) 2013, 6(1): 1-7.

Objective: To examine the effects of a combined endurance/ resistance recreational exercise training on inflammatory and lipid markers in type 2 diabetic patients with oral medication type 2 diabetes.

Materials and methods: 63 type 2 diabetes patients, aged 65±9years, with oral medication had a 6 months recreational physical exercise training two times/week for 1h. Plasma levels of C-reactive protein (s-CRP), tumor necrosis factor (TNF)-alpha, interleukin-6 (IL-6), triglyceride, cholesterol, HDL, LDL and specific diabetic parameters were measured at baseline and after 3 and 6 months training period.

Results: Physical exercise training resulted after 3 months in a significant increase of IL-6 (2.64 ± 1.40 vs. 2.09 ± 1.66 pg/l) and a very significant decrease of TNF-alpha (12,02 ± 12.53 vs. 11.62 ± 4.92 pg/l). After 6 months no significances in inflammatory markers were seen when compared to baseline levels. Antilipemics and physical training induced no significant decrease in lipidprofile. Patients without antilipemics showed a very significant increase in triglycerides after 6 months (1.65±0.10 vs. 2.05±1.52 mmol/l) and a significant decrease in LDL after 3 months (3.41±0.77 vs. 3.28± 0.81mmol/l) and remained in this level without significance to baseline after 6 months (3.28±0.82 mmol/l). The differences in cholesterol and LDL between these groups were very significant. After 6 months HbA1c and weight remained unaffected (6.29 ± 0.96 vs. 6.39 ± 0,77 % and 88.60 ± 18.70 vs. 88.03 ± 17.59 kg).

Conclusion: A 6 months rehabilitative exercise training in type 2 diabetic patients with oral medication two times a week has no persistent significant effect on inflammatory and lipid marker levels.

Keywords: Physical exercise, diabetes mellitus, CRP, TNF-alpha, IL-6, systemic inflammation, lipid profile

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